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Commit 190f7716 authored by Gervaise Henry's avatar Gervaise Henry :cowboy:
Browse files

Make former lab member

parent cf5cfb72
3 merge requests!9Develop,!4Develop,!1Update
......@@ -8,5 +8,6 @@ pic: "NoPic.jpg"
tit: ""
orcid: ""
weight: ""
current: true
---
......@@ -89,22 +89,23 @@ layout: "data"
<div align = "center">
<h1 id="label.gene">NO GENE SELECTED</h1>
<h2 id="label.lineage"></h2>
<h3 id="label.populations"></h3>
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<h3 id="label.ClusterVis"></h3>
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......@@ -8,6 +8,7 @@ pic: "henry_g.jpg"
tit: "Research Technician"
orcid: "0000-0001-7772-9578"
weight: "10"
current: true
---
Gervaise obtained his master's degree at American University in 2015. He joined Dr. Strand’s lab in 2015.
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......@@ -8,6 +8,7 @@ pic: "joseph_d.jpeg"
tit: "Postdoctoral Researcher"
orcid: "0000-0002-0587-9558"
weight: "4"
current: true
---
Diya obtained her PhD at the University of Wisconsin: Madison in the Vezina Lab. She joined the Dr. Strand's Lab in 2019.
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......@@ -8,6 +8,7 @@ pic: "malewska_a.jpg"
tit: "Research Technician"
orcid: ""
weight: "5"
current: true
---
Alicia obtained her master's degree at UT Dallas in 2005 and has worked at UT Southwestern ever since. She joined Dr. Strand’s lab in 2014.
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......@@ -8,6 +8,7 @@ pic: "mcalanis_c.jpg"
tit: "STARS Student (2019)"
orcid: ""
weight: "15"
current: false
---
Senior at North Forney High School. Caitlin is joining us in the Strand lab for the summer of 2019.
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While a senior at North Forney High School, Caitlin joined us in the Strand lab for the summer of 2019.
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......@@ -8,6 +8,7 @@ pic: "strand_d.jpg"
tit: "Assistant Professor of Urology"
orcid: "0000-0002-0746-927X"
weight: "1"
current: true
---
Doug obtained his Ph.D. with David Rowley at Baylor College of Medicine in the department of Molecular and Cellular Biology. He did a postdoctoral fellowship at Vanderbilt University under Simon Hayward. He joined the faculty of UTSW in 2014.
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---
title: "BioRepository"
date: 2019-07-07T22:25:54-05:00
draft: true
type: "custom"
layout: "repository"
---
---
title: "BioRepository"
date: 2019-07-07T22:25:54-05:00
draft: true
type: "custom"
layout: "repository"
---
......@@ -10,6 +10,7 @@ draft: true
clear: both;
}
div.fig {
align: center;
max-width: 500px;
padding: 1px;
border: 1px solid black;
......@@ -81,6 +82,6 @@ One of the factors that likely causes a variable response to medical therapy is
The human prostate sits at the base of the bladder, which releases urine through the prostatic urethra. Ureters connect to the kidneys, vas deferens connect to the testicles. Sperm from the testicles, and secretory fluids from the seminal vesicles and prostate are forced through into the prostatic urethra during ejaculation. The human prostate is divided into 4 major ‘zones’: the transition zone (TZ), which is an area than encircles the prostatic urethra from the base at the bladder neck to the apex at the start of the penis; the central zone (CZ) encircles the ejaculatory ducts from the seminal vesicles; the peripheral zone (PZ) encompasses the posterior prostate surrounding the TZ and CZ; and the anterior fibromuscular stroma (AFS).
</p>
<p style="text-align:justify; font-size:18px;">
The first step towards personalized therapy for BPH phenotypes is to understand the cellular anatomy of the normal prostate. The prostate is mainly composed of epithelial and stromal cell types. Historically, the definition of prostate epithelial cell type has been based on 1) the relative position of cells within glandular acini, 2) cellular shape, and 3) the differential expression of genes and cell surface antigens. Using these criteria, prostate glands are reportedly composed of basal and luminal epithelia with rare neuroendocrine cells. Basal epithelia express cytokeratins 5/14 as well as the transcription factor p63. Luminal epithelia express cytokeratins 8/18 as well as androgen receptor. A putative intermediate cell ‘state’ between luminal and basal lineages has been defined on the basis of shared expression of luminal and basal cytokeratins. Neuroendocrine epithelia are defined by expression of markers such as chromogranin A. The stroma is even more poorly defined as generic smooth muscle and fibroblast cell types. Our laboratory is using single cell sequencing and flow cytometry to define the cellular composition of the normal prostate procured from young organ donors through a partnership with the Southwest Transplant Alliance. These data will establish a baseline against which various diseased phenotypes can be compared. We currently have a biorepository of normal and diseased human prostate containing paraffin blocks, OCT blocks, flash frozen tissue, and cryopreserved single cells available upon request (see Resources page). You can also search our single cell sequencing dataset with our ProstateMapper tool to see where your gene of interest is expressed in the normal prostate.
The first step towards personalized therapy for BPH phenotypes is to understand the cellular anatomy of the normal prostate. The prostate is mainly composed of epithelial and stromal cell types. Historically, the definition of prostate epithelial cell type has been based on 1) the relative position of cells within glandular acini, 2) cellular shape, and 3) the differential expression of genes and cell surface antigens. Using these criteria, prostate glands are reportedly composed of basal and luminal epithelia with rare neuroendocrine cells. Basal epithelia express cytokeratins 5 / 14 as well as the transcription factor p63. Luminal epithelia express cytokeratins 8 / 18 as well as androgen receptor. A putative intermediate cell ‘state’ between luminal and basal lineages has been defined on the basis of shared expression of luminal and basal cytokeratins. Neuroendocrine epithelia are defined by expression of markers such as chromogranin A. The stroma is even more poorly defined as generic smooth muscle and fibroblast cell types. Our laboratory is using single cell sequencing and flow cytometry to define the cellular composition of the normal prostate procured from young organ donors through a partnership with the Southwest Transplant Alliance. These data will establish a baseline against which various diseased phenotypes can be compared. We currently have a biorepository of normal and diseased human prostate containing paraffin blocks, OCT blocks, flash frozen tissue, and cryopreserved single cells available upon request (see Resources page). You can also search our single cell sequencing dataset with our ProstateMapper tool to see where your gene of interest is expressed in the normal prostate.
</p>
</div>
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......@@ -48,6 +48,7 @@
<!-- alert(_gene) -->
document.getElementById("label.gene").innerHTML = _gene
document.getElementById("label.lineage").innerHTML = $("#lineage").val().toUpperCase() + " Cells"
document.getElementById("label.populations").innerHTML = "Separated by " + $("#populations").val().toUpperCase()
document.getElementById("label.ClusterVis").innerHTML = "Cluster Visualization"
var img = document.getElementById("img.ClusterVis");
img.src="/images/scRNAseq_huPr_D/png/ID/" + $("#lineage").val() + "/" + $("#populations").val() + "/ClusterVis.png"
......
......@@ -30,8 +30,33 @@
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<hr>
<h1>Former Members</h1>
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......
......@@ -24,6 +24,7 @@
<h2>{{ .Description }}</h2>
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