diff --git a/README.md b/README.md index 1e1b4869a4e72f93cd3e3d75b35c8fdfd4ecdebe..b36447b266276e1d14d582ca37f11b88b0940a0d 100755 --- a/README.md +++ b/README.md @@ -15,6 +15,22 @@ Data Analysis ------------- * **Requirements:** + * /analysis/DATA/D17PrF/ + * D17PrF-demultiplex.csv + * 10x/ + * aggregation_csv.csv + * GRCh38/ + * "barcodes.tsv" + * "genes.tsv" + * "matrix.mtx" + * /analysis/DATA/D27PrF/ + * D27PrF-demultiplex.csv + * 10x/ + * aggregation_csv.csv + * GRCh38/ + * "barcodes.tsv" + * "genes.tsv" + * "matrix.mtx" * 10x CellRanger analyzed data: * "filtered\_gene\_bc\_matrice_mex" folder * csv file cellranger aggr used for aggregation @@ -28,8 +44,14 @@ Data Analysis * pastecs (v1.3.21) * qusage (v2.10.0) * RColorBrewer (v1.1-2) + * monocle (v2.6.3) + * dplyr (v0.7.6) * *and all dependencies* - +* **HOW TO RUN** + * 1 Patient D17PrF + * run bash script sc_TissueMapper-D17PrF.sh + * 2 Patients D17PrF and D27PrF + * run bash script sc_TissueMapper-DPrF2.sh * **Pipeline:** * Link cellranger count/aggr output to analysis * Create demultiplex file to add custom sample groups @@ -77,10 +99,6 @@ Data Analysis * "genes.deg.LE.csv" DWS generated DEGs of luminal epithelial cells from scRNA-Seq of patient D17 only * "genes.deg.OE1.csv" DWS generated DEGs of "other" epithelia cluster 1 cells from scRNA-Seq of patient D17 only * "genes.deg.OE2.csv" DWS generated DEGs of "other" epithelia cluster 2 cells from scRNA-Seq of patient D17 only - * "" DWS generated DEGs of basal epithelial cells from scRNA-Seq of an aggregation of patient D17 and D27 - * "" DWS generated DEGs of luminal epithelial cells from scRNA-Seq of an aggregation of patient D17 and D27 - * "" DWS generated DEGs of "other" epithelia cluster 1 cells from scRNA-Seq of an aggregation of patient D17 and D27 - * "" DWS generated DEGs of "other" epithelia cluster 2 cells from scRNA-Seq of an aggregation of patient D17 and D27 * Stroma: * "DEG\_C5.BP.M11704.txt" MSigDB C5 GO Biological Processes M11704 [**GO\_ENDOTHELIAL\_CELL\_DIFFERENTIATION**](http://software.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_DIFFERENTIATION.html) * "DEG\_C5.BP.M10794.txt" MSigDB C5 GO Biological Processes M10794 [**GO\_SMOOTH\_MUSCLE\_CELL\_DIFFERENTIATION**](http://software.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html)